Trans-Scleral Permeability of Oregon Green 488®
نویسندگان
چکیده
منابع مشابه
Enhancement of scleral macromolecular permeability with prostaglandins.
PURPOSE It is proposed that the sclera is a metabolically active and pharmacologically responsive tissue. These studies were undertaken to determine whether prostaglandin exposure can enhance scleral permeability to high-molecular-weight substances. METHODS Topical prostaglandin F2 alpha (PGF2 alpha) was administered to monkeys to determine if this altered the amount of scleral matrix metallo...
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PURPOSE In this study, we investigated the penetration of various proteins into the mouse eye after a periocular injection of the protein or an adenoviral vector (Ad) expressing the protein. METHODS At several time points after the injection, the retina, retinal pigmented epithelium/choroid, and sclera were dissected and enzyme-linked immunosorbent assays were performed. RESULTS After a per...
متن کاملIncreased human scleral permeability with prostaglandin exposure.
PURPOSE To investigate the effect of prostaglandins (PGs) on the permeability of human sclera in vitro. METHODS Twenty-three pairs of human eye bank eyes were studied. Circular pieces of sclera were cultured in low-serum DMEM/F-12 media. Scleral hydration was assessed by measuring wet and dry weight of scleral cultures incubated with medium for 3 days and with Hanks' buffered saline solution ...
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Developing more effective ocular drug delivery systems is essential to improving the treatment of posterior segment eye disease. The large target area provided by the sclera and potentially less vision threatening complications are advantages of transscleral administration compared to more traditional modalities of drug delivery to the posterior segment. We aimed to determine the permeability c...
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Anselmo G. De Oliveira1, José A. Cardillo2,3, Fernando Paganelli2,3, Acácio A. S. Lima-Filho2 and Arnóbio A. Da Silva-Júnior4 1State of Sao Paulo University-UNESP, School of Pharmaceutical Sciences, Department of Pharmaceutics, Araraquara, SP, 2Federal University of Sao Paulo-UNIFESP, Department of Ophthalmology, São Paulo, SP, 3Eye Hospital of Araraquara, Rua Padre Duarte, Araraquara, SP, 4Fed...
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ژورنال
عنوان ژورنال: Journal of Ocular Pharmacology and Therapeutics
سال: 2008
ISSN: 1080-7683,1557-7732
DOI: 10.1089/jop.2008.0050